When playing Dragon Link, the best denomination to play with is the highest denomination that you can afford. This is because the higher the denomination, the higher the potential payout. For example, if you are playing with a $1 denomination, you can only win up to $1,000. However, if you are playing with a $5 denomination, you can win up to $5,000.
Of course, the higher the denomination, the more risk there is involved. This is because you are more likely to lose your money if you are playing with a higher denomination. However, if you are willing to take on the risk, playing with a higher denomination can be a great way to increase your winnings.